ProSci

TNFSF11 Recombinant Protein

Product Code:
 
PSI-96-959
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-959-0.05mg0.05mg£729.00
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Further Information

Additional Names:
RANKL,CD254,TRANCE,OPGL,ODF
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.
Background References:
  • Hanada R., et al., 2011, J. Mol. Med. 89 (7): 647-656.
  • Findlay DM., et al., 2011, Osteoporos Int. 22 (10): 2597-2602.
  • Schmiedel BJ., et al., 2013, Cancer Res. 73 (2): 683-694.
  • Castellano D., et al., 2011, Oncologist. 16 (2): 136-145.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human TNFRSF11A at 5 ug/mL (100 uL/well) can bind Human TNFSF11, His Tag with a linear range of 0.2-6 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
8600
NCBI Official Name:
TRANCE, partial
NCBI Official Symbol:
TNFSF11
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
22.4 kDa
Protein Accession #:
AAC51762.1
Purity:
>90% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
AAC51762.1

Documents