ProSci

OX40 Ligand Recombinant Protein

Product Code:
 
PSI-97-018
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-97-018-0.1mg0.1mg£657.00
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Further Information

Additional Names:
OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
Background References:
  • Medinger M, Tzankov A,et al., 2011, Thromb Haemost. 105:72-80.
  • Yue W, Sun Q, et al., 2008, Carcinogenesis. 29(1):84-92..
  • Pinho S, Niehrs C.et al., 2007, Differentiation. 75(10):957-67.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Mouse OX40, His Tag at 2 ug/mL (100 uL/well) can bind Mouse OX40 Ligand, Fc Tag with a linear range of 2-30 ng/mL.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
22164
NCBI Official Name:
Tumor necrosis factor ligand superfamily member 4
NCBI Official Symbol:
OX40 Ligand
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
44.5 kDa
Protein Accession #:
P43488
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P43488

Documents