ProSci

VEGF R2 Recombinant Protein

Product Code:
 
PSI-97-070
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Rhesus Macaque
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-97-070-0.1mg0.1mg£657.00
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Further Information

Additional Names:
KDR,CD309,FLK1,VEGFR,VEGFR2
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Background References:
  • Holmes K,et al., 2007, Cell Signal. 19 (10): 2003?2012.
  • Stuttfeld E, et al., 2009, IUBMB Life 61 (9): 915?22.
  • Fujita, N, et al., 2008, Biochemical and biophysical research communications 372 (2): 367?372.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human VEGF165 at 2 ug/mL (100 uL/well) can bind Rhesus macaque VEGF R2, His Tag with a linear range of 4-60 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
698293
NCBI Official Name:
kinase insert domain receptor
NCBI Official Symbol:
VEGF R2
NCBI Organism:
Macaca mulatta
Physical State:
Lyophilized
Predicted Molecular Weight:
85.2 kDa
Protein Accession #:
F7E313
Purity:
>97% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
F7E313

Documents