AdipoGen Life Sciences

anti-TRAM (human) pAb (AL239)

Product Code:
 
AG-25B-0011
Product Group:
 
Primary Antibodies
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
-20°C
Storage:
 
-20°C
 

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AG-25B-0011-R05050 ul£100.00
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Further Information

Alternate Names/Synonyms:
TRIF-related Adapter Molecule; TIRP; Toll-Interleukin 1 Receptor [TIR] Domain-containing Protein; TICAM-2; TIR-containing Adapter Molecule-2
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. Neat serum containing 0.02% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
Synthetic peptide corresponding to aa 2-29 (G2IGKSKINSCPLSLSWGKRHSVDTSPGY29) of human TRAM.
Long Description:
Polyclonal Antibody. Recognizes human TRAM. Source: Rabbit. Applications: WB. Liquid. Neat serum containing 0.02% sodium azide. TRAM functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. It is also involved in IL-1-triggered NF-kappaB activation, functioning upstream of IRAK1, IRAK2, TRAF6 and IKBKB. TRAM physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TRL4 signal to TICAM-1. It is expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle and pancreas.
NCBI, Uniprot Number:
Q86XR7
Package Type:
Plastic Vial
Product Description:
TRAM functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. It is also involved in IL-1-triggered NF-kappaB activation, functioning upstream of IRAK1, IRAK2, TRAF6 and IKBKB. TRAM physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TRL4 signal to TICAM-1. It is expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle and pancreas.
Source / Host:
Rabbit
Specificity:
Recognizes human TRAM.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells: E. Aksoy, et al.; Blood 109, 2887 (2007)