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Showing 25 of 803 items meeting your criteria.
| Type | Category | Supplier | ||
|---|---|---|---|---|
 | IDH1/2 Mutations | |||
Documents | Cancer | Abnova Corporation | ||
 | Androgen receptor (AR) is a member of the steroid receptor transcription factor family. In prostate cancer, increased levels of androgens in the tumor cells promote (1) AR signaling associated with cell-cycle regulation, growth, and survival, and (2) the expression of oncogenic fusion genes. AR-V7 is one of the splice variants of AR lacking the C-terminal LBD,
but being constitutively active as a transcription factor and capable of promoting activation of target genes. | |||
Documents | Cancer | Abnova Corporation | ||
 | Inactive monomeric heat shock factor 1 (HSF1) exists predominantly in the cytoplasm and remains repressed by complex with regulatory proteins of HSF1 its own transcriptional targets of heat-shock protein (HSP) and cytosolic chaperonin TCP1 ring complex (TRiC). Upon a wide range of stress conditions, HSF1 is activated to undergo trimerization, nuclear translocation, and post-translational modifications (PTMs) including phosphorylation, acetylation, and sumoylation, converted into a DNA-binding-competent, active homotrimer. HSF1 is then modified by different inhibitory PTMs to cause DNA dissociation, HSF1 inactivation, and HSF1 recycling/degradation and maintained in a negative-feedback mechanism. | |||
Documents | Antibodies | Abnova Corporation | ||
 | Complement System ELISA Kits - Complement Components, Complement Regulators, Complement Receptors and Complement Lectin Pathway Targets from Abnova. | |||
Documents | ELISA | Abnova Corporation | ||
 | Popular ELISA & Assay Kits | |||
Documents | Kits | Abnova Corporation | ||
 | Microglia Function Transition. | |||
Documents | Antibodies | Abnova Corporation | ||
 | NLRP3 activation can occur through both potassium-dependent and potassium-independent mechanisms. Potassium-dependent mechanisms depend on potassium efflux upon MLKL activation, opening of P2X7 channel or exposure to pore-forming toxins. Potassium-independent activation is mediated through metabolic perturbation. | |||
Documents | Inflammation | Abnova Corporation | ||
 | Full-length mutant huntingtin (mHTT) can be further processed to generate smaller fragments and the amino-terminal HTT exon1 protein fragments are formed by aberrant splicing. Fragments can undergo self-association, oligomerization, and aggregation in the nucleus and cytoplasm, leading to the formation of inclusions that cause numerous pathogenic mechanisms, including synaptic dysregulation, mitochondrial toxicity, energy imbalance, and impaired axonal transport in Huntington’s disease. | |||
Documents | Antibodies | Abnova Corporation | ||
 | Inhibition of BAK Activation in the Microenvironment. B cell receptor associated kinases (BAKs) are expressed in not only B cells but also other cell types, and regulate the signaling of other surface receptors within the tumor microenvironment (TME). Evidence has suggested that BAK inhibitors could disrupt the crosstalk between malignant B cells and their microenvironment by suppressing the function of BAKs in those non-tumor cells. | |||
Documents | Kinase | Abnova Corporation | ||
 | While several studies discovered the therapeutic potential of receptor tyrosine kinase (RTK) inhibition, research has recently put a spotlight on novel kinase targets that influence basal cellular process in cancer. Cyclin-dependent kinase (CDK) is one of the new areas that has been focused. As transcription-associated kinases, CDKs represent opportunities for the development of druggable targets for transcriptional-addicted cancers. | |||
Documents | Kinase | Abnova Corporation | ||
 | Tumor-Associated Antigens of CAR T Cell Therapy | |||
Documents | Antibodies | Abnova Corporation | ||
 | Immunoglobulin ELISA Kits | |||
Documents | ELISA | Abnova Corporation | ||
 | Several PD-associated genes interact with pathways regulating mitochondrial homeostasis. The mutations in these genes encoding proteins, like VPS35, PINK1 and LRRK2, lead to mitochondrial dysfunction and further drive the development of neurodegeneration in PD. | |||
Documents | Proteins | Abnova Corporation | ||
 | Cell culture has become essential to small and large scale monoclonal antibody productions. Abnova uses a specialized protocol for generating cell culture grade antibodies. Compared to classic cell culture, this method allows for multiple harvests, longer run times and higher concentrated supernatant, and provides customers high purified antibodies with minimal to zero contamination. | |||
Documents | Antibodies | Abnova Corporation | ||
 | Abnova have over 300 camelid single domain antibodies (sdAbs), derived from alpacas or llamas, with great penetrability and affinity to recognize difficult epitopes. The product lines include FluoTag-Q, FluoTag-X2 and FluoTag-X4, featuring different number of sdAb and coupled fluorophore. | |||
Documents | Antibodies | Abnova Corporation | ||
 | On February 11, 2020, the novel coronavirus which, at the end of 2019, had been identified as causing severe respiratory disease, was officially named 'Coronavirus Disease 2019'. What is Abnova’s action to support the global response to COVID-19? They offer a range of tools to assist researchers in accelerating infectious disease research, and help healthcare workers deal with the high demand for testing. | |||
Documents | COVID-19 | Abnova Corporation | ||
 | A list of Abnova antibodies, proteins and ELISA kits that are specific for Coronaviruses. | |||
Documents | Antibodies | Abnova Corporation | ||
 | Abnova offers recombinant human monoclonal antibodies raised against various SARS-CoV or SARS-CoV-2 proteins. These antibodies include humanized and fully human monoclonal antibodies which are much less immunogenic than the original mouse antibodies, but have improvement in their activation of the human immune system. | |||
Documents | Antibodies | Abnova Corporation | ||
 | Abnova offers RNA markers for precise size determination of double-strand or single strand RNA molecules in denaturing acrylamide gels. These RNA markers consist of RNA transcripts with various size ranges, which are useful for estimating the amount of RNA samples based on your research needs. | |||
Documents | RNA | Abnova Corporation | ||
 | Angiotensin-converting enzyme 2, or ACE2 receptor, is a protein attached to the surface of many cell types. It serves as the entry point for coronavirus, including HCoV-NL63, SARS-CoV, and SARS-CoV-2 to connect and infect a wide range of human cells. Abnova offers a variety of bioreagents targeting ACE2 and other ACE2 related targets. | |||
Documents | Antibodies | Abnova Corporation | ||
 | COVID-19 Viral Antigen ELISA Kits are sandwich enzyme-linked immunosorbent assay for the quantitative measurement of COVID-19 viral spike antigens or nucleocapsid antigens. | |||
Documents | ELISA | Abnova Corporation | ||
 | Neutralizing antibodies are able to block the interaction between viruses and host cells, which can potentially stop the infection. Abnova has developed a group of SARS-CoV-2 S monoclonal antibodies, which are neutralizing mouse monoclonal antibodies targeting recombinant SARS-CoV-2 spike protein. | |||
Documents | Antibodies | Abnova Corporation | ||
 | Best Selling ELISA Kits from Abnova - Infectious Diseases | |||
Documents | ELISA | Abnova Corporation | ||
 | Abnova ELISA kits to quantify physiologic hormones. Abnova provides a complete collection of metabolic, androgen, reproductive, thyroid, mineral & bone, and stress hormone ELISA kits across multiple mammalian species. | |||
Documents | ELISA | Abnova Corporation | ||
 | A comprehensive listing of Abnova's Cas9, Cas12, Cas13 nucleases and nickases, accompanied by validated monoclonal, polyclonal, and conjugated antibodies. | |||
Documents | Proteins | Abnova Corporation | ||