Circular RNA sponge, also known as circRNA sponge, is a synthetic RNA molecule derived from in vitro transcription (IVT) and circularization by permutated intron exon (PIE) or enzymatic ligation. circRNA sponge acts as a competitive inhibitor of specific miRNA. It contains multiple binding sites (MREs) for sequestering and "sponging" miRNA, thus preventing miRNA interaction with endogenous target mRNA. Compared to linear RNAs, circRNA sponges lack 5 cap and 3 poly(a) tail and are more resistant to exonucleolytic degradation resulting in higher intracellular levels for miRNA target derepression. circRNA sponges overcomes the toxicity exhibited by anti-miRNA oligonucleotides (AMO) and dosage constraint by the plasmid-based miRNA sponge. circRNA sponges does not require nucleoside modifications and are inherently non-immunogenic. A multitude of circRNA sponge reagents is coming soon.
Abnovas Research Grade Biosimilars are reliable, cost-effective alternatives for scientific advancement. With comparable efficacy and safety profiles, Abnovas Biosimilars open new research possibilities for assays, cell culture, and preclinical research.
Cloud-Clone High Sensitive ELISA Kits have more advantages in terms of sensitivity, ideal when the concentration of target analyte is too low to measure, such as low level cytokines.
Pattern recognition receptors (PRRs) are crucial for detecting invading pathogens and initiating the innate and adaptive immune response. There are various families of PRRs including the Toll-like receptors (TLRs), C-type lectin receptors (CLRs), NOD-like receptors (NLRs), RIG-I like receptors (RLRs), and AIM2-like receptors (ALRs). Abnova provide 142 Antibodies, 55 Proteins, and 9 ELISA Kits targeting pattern recognition receptors.
Enterovirus 71(EV71), a non-enveloped and icosahedral single-stranded RNA virus, belongs to family Picornaviridae, genus Enterovirus, species Human Enterovirus A (HEV-A). It is one of the major etiological agents causing hand, foot, and mouth disease (HFMD), which generally affects infants and young children. In addition to HFMD, EV71 epidemic has resulted in many fatalities because of serious neurological complications and has been identified as a serious threat to public health. Abnova has developed high quality Human Enterovirus 71 Antigen ELISA Kit for the qualitative detection of Human Enterovirus 71 Antigen in serum, plasma, cell culture supernatants, cell lysates, tissue homogenates.
Elabscience have developed a series of Metabolism Assay Kits to meet the requirements of researchers, yielding efficient detection of biochemical indicators.
YAP1 encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
SQSTM1 encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
MIF encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.
Cloud-Clone Active proteins based on GMP level development, can provide a variety of specifications of protein, to meet the needs of basic science experiments, drug screening, animal drug delivery and other experiments. High Purity, Multi-species, Multi-specifications, Multi-detections
After 14 years of development and technology accumulation, Cloud-Clone has developed ELISA kit and CLIA kit based on enzyme linked immunoassay technology. 8,000+ kinds of high quality assay kits covering 2,000+ indicators and 10+ species are designed to assist your experimental research. Includes Sandwich ELISA Kit, Competition ELISA Kit, CLIA Kit, Antibody ELISA, Mini ELISA, Instant ELISA, High-sensitive ELISA, Wide-range ELISA.
How do you operate ELISA kits and get a satisfactory test result? What precautions should be paid attention to?
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