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Cytotoxic T Lymphocyte Antigen 4 (CTLA-4; CD152) is an immune checkpoint receptor expressed on the surface of activated T cells.
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Immunology
AdipoGen Life Sciences
TIM-3 plays an important role in autoimmune diseases, chronic viral infections and tumors.
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Immunology
AdipoGen Life Sciences
CD137 (4-1BB; TNFRSF9) is an activating receptor binding to CD137L (4-1BBL; TNFSF9). Because CD137 is expressed on both natural killer (NK) cells and T cells, it can trigger both innate and adaptive immunity. After these cells have been activated by exposure to tumor antigen, CD137 signals stimulate them to reproduce and to generate antitumor activity. CD137 has been shown to play a critical role on T cells in the development of immune memory and the creation of a durable immune response. On lymphocytes, the presence of CD137 appears to be a marker for tumor reactivity. Activation of CD137 signaling can stimulate both cytotoxic T cell and NK cell activity and generate a lasting memory response. Bidirectional CD137/ CD137L signaling also plays an important role in the pathogenesis of autoimmune diseases.
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Immunology
AdipoGen Life Sciences
The CD40-CD40L (CD154) signaling pathway is a pivotal regulator of adaptive immunity, bridging innate and adaptive responses. CD40, a member of the TNF receptor superfamily, is expressed on antigen-presenting cells (APCs) such as dendritic cells, macrophages and B cells, while its ligand CD40L is transiently expressed on activated CD4+ T cells. Engagement of CD40 by CD40L drives a cascade of immune-activating events. In dendritic cells and macrophages, CD40 signaling enhances antigen presentation, cytokine secretion and upregulation of costimulatory molecules. In B cells, CD40-CD40L interactions promote germinal center formation, isotype switching and the generation of long-lived plasma cells and memory B cells. Interaction between CD40-CD40L stimulates cytokines secretion of B cells with subsequent T cell activation and antitumor immunity.
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Immunology
AdipoGen Life Sciences
High-performance antibodies. Ready when you are.
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Antibodies
ProSci
ProSci provides sheep polyclonal antibody production using high-capacity, NIH and USDA-compliant protocols.
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Service
ProSci
ProScis rat polyclonal antibody services combine regulatory-aligned protocols with research-driven agility.
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Service
ProSci
ProSci delivers high-volume rabbit polyclonal antibodies using NIH and USDA-compliant protocols.
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Service
ProSci
Mouse Monoclonal Antibody Packages - Reliable, reproducible antibodies tailored to your targets. Rabbit Recombinant Monoclonal Packages - High affinity. Long-lasting. Fully sequenced.
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Service
ProSci
ProSci delivers high-affinity mouse polyclonal antibodies purpose-built for vaccine development.
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Service
ProSci
ProSci produces high-volume mouse polyclonal antibodies using rigorously validated, NIH- and USDA-compliant protocols.
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Service
ProSci
ProSci specializes in llama and alpaca polyclonal antibody production for projects requiring high-titer IgG at scale.
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Service
ProSci
ProSci delivers guinea pig polyclonal antibodies through a streamlined 66-day protocol, designed for both flexibility and high performance.
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Service
ProSci
ProSci provides goat polyclonal antibody production using high-capacity, NIH-and USDA-compliant protocols.
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Service
ProSci
ProSci supplies high-yield polyclonal antibodies derived from chickens raised and immunized in the Unites States, delivering consistent, milligram-scale quantities of IgY.
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Service
ProSci
At ProSci, we specialize in both polyclonal and monoclonal antibody development—delivering high-quality antibodies tailored to your research needs.
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Service
ProSci
An Introductory Guide for Gene Knockout
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Molecular Biology
Applied Biological Materials (abm)
abms world-leading suite of ready-to-use and custom recombinant viral technologies has something to offer for every project.
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Vectors & Viruses
Applied Biological Materials (abm)
Achieve ultra-high lentiviral titers. Ideal for in vivo gene delivery and transduction experiments. Recovers 80-90% of input virus. Streamlined protocol.
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Vectors & Viruses
Applied Biological Materials (abm)
The only kit on the market with complete elimination of NTC.
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PCR Kits
Applied Biological Materials (abm)
Expert-designed primers - optimized for specificity and efficiency.
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Service
Applied Biological Materials (abm)
Four-plasmid system for lentiviral production. Superior biosafety and high efficiency. Optimized for high titer and performance. Reliable and versatile: package any 2nd or 3rd generation lentiviral vector.
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Vectors & Viruses
Applied Biological Materials (abm)
Three-plasmid system for lentiviral production. Optimal viral titers while maintaining safety. Convenient ready-to-use format. Accelerates workflow.
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Vectors & Viruses
Applied Biological Materials (abm)
Your Trusted Viral Vector Supplier For 20+ Years
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Vectors & Viruses
Applied Biological Materials (abm)
Guaranteed high transfection efficiency even in primary cells. Minimal toxicity. Superior performance in many cell types.
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Transfection
Applied Biological Materials (abm)