iQ Biosciences is a provider of high-quality primary cells specifically peripheral blood mononuclear cells (PBMCs), splenocytes, and bone marrow cells. iQ Biosciences provides human samples, both normal and diseased types but also focus on animal species that are relevant for drug development or academic research, including monkeys, rats, mice, rabbits, dogs, woodchuck, and guinea pigs. They have worked tirelessly on optimizing their products over the past several years to be able to offer world-class products in terms of viability and characterization (example for certain samples, they provide information such as HLA genotyping and immunophenotyping).
In addition to reliably provide focused research support to the pharmaceutical, biotechnology, and diagnostic industries, IQ Biosciences thrives to excel at being a trusted partner of the biomedical community in the fight against unmet patients' need.
Includes Peripheral blood mononuclear cells (PBMCs), Isolated Cells, Splenocytes (SPLs) and Bone Marrow (BM) cells.
Treg Suppression Assay Kit
Regulatory T cells (Tregs) are currently being targeted as a modality to reshape the disease environment to modulate T cell function. In cases of autoimmunity, therapeutics are being developed to enhance Treg function, while in cancer, molecules are developed to abrogate Treg function. To develop these molecules, Treg suppression assays are commonly used to assess whether a potential therapeutic can inhibit or promote Treg function. In these assays, Tregs are co-cultured with responder cells, such as CD8 T cells or PBMCs, and functional readouts of the responder cells are performed at the end of the culture period. Proliferation and cytokine production are often used to assess function.
iQ Biosciences has made it simple to perform these assays with their Human Treg Suppression Assay kit. The kit includes human CD4+CD25+FOXP3+ Tregs validated for suppressive function and your choice of CD8 T cells or PBMCs. The kit contains plenty of cells to evaluate multiple Treg:responder cell ratios to demonstrate functional consistency and provide insights into the potency of Treg modulation if therapeutic molecules are included in the co-cultures.