anti-Methylglyoxal [MG], mAb (3C)

JaICA
Product Code: JAI-MMG-030N
Product Group: Primary Antibodies
Supplier: JaICA

CodeSizePrice
JAI-MMG-030N-30ug30 ug£781.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Antibody Isotype: Mouse IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: 3C
Regulatory Status: RUO
Target Species: Human
Application: Immunohistochemistry (IHC)
Shipping:
BLUE ICE
Storage:
-20°C

Images

1 / 1
Immunohistochemical staining of MG adducts in atherosclerotic aorta using anti-MG, mAb (3C).

Immunohistochemical staining of MG adducts in atherosclerotic aorta using anti-MG, mAb (3C).

Further Information

EClass:
32160000
Form (Short):
liquid
Formulation:
Frozen liquid. Contains 10mM PBS, 0.1% NaN3 and 0.5% BSA.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
MG-modified keyhole-lympet hemocyanine.
Long Description:
Monoclonal Antibody. Recognizes MG-modified proteins (especially Argpyrimidine). Frozen liquid. Contains 10mM PBS, 0.1% NaN3 and 0.5% BSA. Methylglyoxal (MG), an endogenous metabolite that increases in diabetes and is a common intermediate in the Maillard reaction (glycation), reacts with proteins and forms advanced glycation end products (AGE). MG reacts with arginine residue in protein and forms numerous numbers of adducts, such as argpyrimidine.
Package Type:
Plastic Vial
Product Description:
Methylglyoxal (MG), an endogenous metabolite that increases in diabetes and is a common intermediate in the Maillard reaction (glycation), reacts with proteins and forms advanced glycation end products (AGE). MG reacts with arginine residue in protein and forms numerous numbers of adducts, such as argpyrimidine.
Specificity:
Recognizes MG-modified proteins (especially Argpyrimidine).
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 3 years after receipt when stored at -20°C.

References

Protein modification by a Maillard reaction intermediate methylglyoxal. Immunochemical detection of fluorescent 5-methylimidazolone derivatives in vivo: K. Uchida, et al.; FEBS Lett. 410, 313 (1997) | Methylglyoxal Modification of Protein -Chemical and Immunochemical Characterization of Methylglyoxal-Arginine Adduct: T. Oya, et al.; J. Biol. Chem. 274, 18492 (1999) | Advanced glycation and lipidoxidation of the peritoneal membrane: respective roles of serum and peritoneal fluid reactive carbonyl compounds: T. Miyata, et al.; Kidney Int. 58, 425 (2000) | Argpyrimidine, a blue fluorophore in human lens proteins: high levels in brunescent cataractous lenses: P.S. Padayatti, et al.; Invest. Ophthalmol. Vis. Sci. 42, 1299 (2001) | High concentrations of glucose induce synthesis of argpyrimidine in retinal endothelial cells: P.S. Padayatti, et al.; Curr. Eye Res. 23, 106 (2001) | Curcumin Inhibits ROS Formation and Apoptosis in Methylglyoxal- Treated Human Hepatoma G2 Cells: W.-H. Chan, et al.; Ann. N.Y. Acad. Sci. 1042, 372 (2005)

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