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AdipoGen Life Sciences

GeA-69

Product Code:
 
AG-CR1-3706
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
-20°C
1 / 1
Chemical Structure
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Chemical Structure

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AG-CR1-3706-M0011 mg£55.00
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Further Information

Alternate Names/Synonyms:
N-(2-(9H-Carbazol-1-yl)phenyl)acetamide
Appearance:
Off-white to light brownish solid.
CAS:
2143475-98-1
EClass:
32160000
Form (Short):
solid
Handling Advice:
Keep cool and dry.Protect from light.
InChi:
InChI=1S/C20H16N2O/c1-13(23)21-18-11-4-2-7-14(18)16-9-6-10-17-15-8-3-5-12-19(15)22-20(16)17/h2-12,22H,1H3,(H,21,23)
InChiKey:
LDPDVNYCIOHPGF-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 2143475-98-1. Formula: C20H16N2O. MW: 300.4. Potent, selective, allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP-14 M2) (Kd=0.86µM, ITC (isothermal titration calorimetry) assay). PARP-14 is an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. Engages PARP-14 MD2 in intact cells displaces adenosine diphosphate ribose (ADPR) from PARP-14 M2 and prevents recruitment of the PARP-14 M2 to DNA damage sites.
MDL:
MFCD32067870
Molecular Formula:
C20H16N2O
Molecular Weight:
300.4
Package Type:
Vial
Product Description:
Potent, selective, allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP-14 M2) (Kd=0.86µM, ITC (isothermal titration calorimetry) assay). PARP-14 is an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. Engages PARP-14 MD2 in intact cells displaces adenosine diphosphate ribose (ADPR) from PARP-14 M2 and prevents recruitment of the PARP-14 M2 to DNA damage sites.
Purity:
>95%
SMILES:
O=C(C)NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43
Solubility Chemicals:
Soluble in DMSO (2mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14: M. Schuller, et al.; ACS Chem. Biol. 12, 2866 (2017) | Discovery of a novel allosteric inhibitor scaffold for polyadenosinediphosphate-ribose polymerase 14 (PARP14) macrodomain 2: M. Moustakim, et al.; Bioorg. Med. Chem. 26, 2965 (2018)