anti-PARP-1 [ARTD1] (human) pAb
| Code | Size | Price |
|---|
| AG-25T-0002-R100 | 100 ul | £190.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Monkey
- Mouse
Applications:
- Immunocytochemistry (ICC)
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
-20°C
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
Poly(ADP-ribose) Polymerase 1; ADP-ribosyltransferase Diphtheria Toxin-like 1; NAD(+) ADP-ribosyltransferase 1
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. Contains 0.1% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant human PARP-1 [ARTD1] (aa 215-525).
Long Description:
Polyclonal Antibody. Recognizes human PARP-1. Cross-reacts weakly with mouse and monkey PARP-1. Source: Rabbit. Applications: ICC, IHC, IP, WB. Liquid. Contains 0.1% sodium azide. PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
NCBI, Uniprot Number:
P09874
Package Type:
Plastic Vial
Product Description:
PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Source / Host:
Rabbit
Specificity:
Recognizes human PARP-1. Cross-reacts weakly with mouse and monkey PARP-1.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice: V. Petrilli, et al.; J. Clin. Invest. 114, 1072 (2004) | Acetylation of PARP-1 by p300/CBP regulates coactivation of NF-kappa B-dependent transcription: P.O. Hassa, et al.; J. Biol. Chem. 280, 40450 (2005)