UK and Ireland Distributor of MBL International - Antibodies, Assay Kits, Tetramers and Reagents for Life Science Research and Clinical Diagnostics

MBL

Established in 1993, MBL International Corporation (MBLI) is a leading life science company focused on providing high quality, innovative, solutions-based products for both life science research and clinical diagnostics. Their products are used widely in academic research institutions, pharmaceutical and biotechnology companies, government agencies as well as hospital and reference laboratories.

The MBLI product range can be divided into five distinct categories:

Life Science Research

General Reagents

MBLI develops, manufactures, and markets a broad portfolio of monoclonal and polyclonal antibodies, fluorescent and recombinant proteins and ELISA kits for research related to allergy, apoptosis, autophagy, cancer, epigenetics, immunology, and neuroscience.

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MHC Tetramers: Directly Measure Antigen-Specific T Cells

MBLI has a wide portfolio of immune monitoring research products including tetramer technology for vaccine development, rapid T-cell detection and quantification in the pharmaceutical industry or bioresearch industry.

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Drug Discovery Tools

MBL International Corporation offers fluorescent protein-based drug discovery tools for use in living cells. Their novel technology, Fluoppi, can visualise Protein-Protein Interaction (PPI) of interest in living cells. Moreover, other product offering such as Keima-Red and FUCCI, can visualise autophagy/mitophagy and cell cycle respectively. These technologies are applicable for cell-based high-throughput drug screening.

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Clinical Diagnostics

Detection of Autoimmune Diseases

Autoimmune diseases are classified into systemic autoimmune disease and organ-specific autoimmune disease. MBLI offers a wide variety of ELISA and immunofluorescence assays (IFA) for the detection of disease-related autoantibodies including anti-nuclear antibodies and anti-desmosomal structural protein antibodies.

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Blog posts

Explore the Limitless Potential of IL-18

Researchers take advantage of MBL International's recombinant IL-18 to activate varying cells like peripheral blood cells, macrophages, NK cells and T cells to identify targets.

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The invaluable role of QuickSwitch™ kits in validating predicted results

Wang, Wenfeng, et al 2023, selected the top 15 top peptides for self-antigen for their study. By using the QuickSwitch™ kit, they successfully switched 6 peptides to the tetramer complex with an efficiency of over 75%.

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Caspase Activity: Essential for Apoptosis

MBLI 's APOPCYTO Caspase-3,8,9 Colorimetric Assay Kit detects caspase activity in cell extract with LEHD-pNA as a substrate, in which LEHD sequence is recognised by each active caspase selectively.

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Ensure Accurate Immune Monitoring Results with Negative Controls

Negative controls aid precision of immune response monitoring. For HLA-A*02:01 alleles, MBLI offers a “Negative Tetramer” in BV421, PE or APC.

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Visualising Protein-Protein Interaction with FLUOPPI Technology

MBLI's innovative technology, Fluoppi, simplifies the visualisation of protein-protein interaction.

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Validation of Neoantigen In Silico Prediction using QuickSwitch™ Kits

Research findings indicate that neoantigens have the potential to activate tumour-specific T-cell-mediated anti-tumour immune responses.

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Therapeutic Targets of the NAD+ Biosynthesis Pathway

CycLex NAMPT Colorimetric Assay Kit detects nicotinamide phosphoribosyltransferase (NAMPT) activity in recombinant NAMPT or endogenous NAMPT immunoprecipitated from cell extract.

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Cancer Immunotherapy: An increasing emphasis on CD4+ T cells and MHC Class II Neoantigens

QuickSwitch™ Class II Tetramer Peptide Exchange and Quantitation Kit utilises a patented technique for exchanging up to ten peptides on an MHC Class II Tetramer.

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Discover the Ab-Match ELISA Series: Unveiling Cancer Biomarkers and Beyond

The Ab-Match series by MBL are innovative ELISA kits for the detection of cancer antigens. These convenient kits come with all the necessary components for successful detection.

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Tetramer Gating Strategy For True Positives Results

Investigators have developed a gating strategy that effectively minimises non-specific staining by incorporating a dump channel.

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Histone deacetylase (HDAC): important consideration in regulating gene expression

Histone deacetylase (HDAC) plays a pivotal role in the regulation of gene expression through the modification of nucleosome structure.

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Correlation Between HLA Typing and Immune Monitoring in Human Disease

The human leukocyte antigen system, aka human major histocompatibility complex, was named after its discovery with alloantibodies against leukocytes.

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Protein Phosphorylation: Essential Role in the Proper Functioning of Pathways

MBLI offers Assay/Inhibitor screening kits designed to measure the activities of purified kinase for the rapid and sensitive evaluation of inhibitors.

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Non-classical MHCs mediate activation or inhibition in natural killer (NK) cells: HLA-E, Qa-1b, and MR1

MBL International offers tetramers for the following non-classical MHC targets: HLA-E, Qa-1b, and MR1.

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S100 Proteins Regulate Metabolic and Immune Pathways to Influence Disease State

Involved in diverse cellular pathways & diseases, S100 proteins play a vital role in intricate workings of cells. MBL has a variety of S100 ELISA kits.

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Leveraging Anti-Integrin αvβ6 Antibodies for Ulcerative Colitis

MBLI is proud to introduce the Anti-Integrin αvβ6 ELISA Kit that readily allows measurement of anti-integrin αvβ6 antibody levels in human serum.

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