Applied Biological Materials (abm)

Human IFNLR1 CRISPR Knockout A549 Stable Cell Line

Product Code:
 
ABM-T3518
Product Group:
 
Cell Lines
Host Type:
 
Human
Regulatory Status:
 
RUO
 

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ABM-T35181x10^6 cells / 1.0 mlEnquire
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Further Information

Description:
This A549 cell line features a CRISPR/Cas9 mediated stable knockout of IFNLR1 which encodes the interferon lambda receptor 1, an essential component of the type III interferon receptor complex. This knockout cell line is an invaluable resource for investigating the role of IFNLR1 in immune response, antiviral defense mechanisms, and cytokine signaling pathways. Applications of this stable cell line extend to research in immunology, virology, and drug discovery, facilitating the development and evaluation of new antiviral agents and immunotherapeutics.Complete list of cell lines from this panel: Cat. T3517 - Human IFNAR1 CRISPR Knockout A549 Stable Cell LineCat. T3518 - Human IFNLR1 CRISPR Knockout A549 Stable Cell LineCat. T3519 - Human IFNAR1-IFNLR1 CRISPR Knockout A549 Stable Cell Line
Donor History:
Male, 58, White, lung cancer
Growth Conditions:
PriCoat™ T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) are recommended for optimal cell culture. F-12K Medium (Kaighn's Modification of Ham's F-12 Medium) + 10% Heat-inactivated FBS + 1% Penicillin/Streptomycin Solution (G255), 37.0°C, 5% CO2.
Growth Properties:
Adherent, epithelial-like
Markers:
Human IFNLR1 knockout
Population Doubling:
24
Tissue:
Lung

References

Czerkies, M., Kochańczyk, M., Korwek, Z., Prus, W., & Lipniacki, T. (2022). Respiratory Syncytial Virus Protects Bystander Cells against Influenza A Virus Infection by Triggering Secretion of Type I and Type III Interferons. Journal of virology, 96(22), e0134122. https://doi.org/10.1128/jvi.01341-22