Atelerix - Preserve & Transport Fresh Cells, Tissues & Blood, Without Cryopreservation - Distributed in the UK by Caltag
Atelerix
Atelerix was founded by a team of scientists who saw the limitations of cryopreservation - and knew there had to be a better way. Spun out from world-class research in Newcastle in 2017, Atelerix has grown into a platform for scalable, ambient preservation.
Atelerix's patented alginate hydrogel technology stabilises cells, tissues, blood products, vectors and viruses at room temperature.
Today, they're helping researchers, biotech firms and diagnostics teams store and ship cells and tissues with preserved viability, without the cold chain.
See the Products Available:
The Technology
Atelerix's plant-based hydrogels are pharmaceutical-grade, high-purity alginates, derived from brown seaweed, which are highly characterised and consistent. The alginate formulations have been optimised specifically for cell storage and protocols streamlined for ease of use and scalability.
Upon exposure of the liquid non-crosslinked alginate to free cations, gelation occurs encapsulating your precious cell, tissue, or virus sample, which stabilises lipid membrane integrity during hypothermic storage. Excess ion and water diffusion into the cell is quenched preventing membrane deterioration over time. This keeps the cells alive and in a state of "hibernation" allowing them to be safely stored and/or shipped for extended periods of time. When required, the sample can be quickly released through the addition of a salt-based buffer in a simple cell-friendly process.
All raw ingredients are produced to GMP guidelines and ISO 13485 standards making products readily translatable to regulated applications.
- Extend shelf life of fresh biological products
- Avoid damage associated with freeze-thaw
- Preserve fragile cells and complex physiologically relevant cell-based models
- Protect from physical damage during shipment
- Avoid complex cryologistics and risk of thaw
Natural biopolymer
No toxic chemicals
Maintain high-quality fresh samples for longer
Xeno-free
Quick & easy to use
BeadReady™
Suitable for suspended and adherent cells
Mix your cells with a gel solution and dispense the mixture dropwise into a gelation solution. As the droplets meet the solution, they form beads that instantly encapsulate the cells. Discard any excess gelation solution and replace with your cells' preferred medium, ready for storage or shipment. When ready to be used, a gentle Dissolution Buffer is added to dissolve the gel. Cells can then be sedimented, resuspended and placed in culture.
Broad range of cell types
Easily image your cells in 3D within a fully transparent hydrogel
Perfect for co-culture due to optimal mass transfer properties
BloodReady™
For the encapsulation of whole blood in a simple, scalable vial format
Simply mix your blood sample with a Gel A solution and transfer it to a tube preloaded with BloodReady™ beads. After a few minutes, the whole blood and Gel mixture will gel in situ and is ready for storage or shipment at 2–8°C. When ready to use, a gentle Dissolution Buffer is added to dissolve the gel, the beads are filtered out, and the whole blood sample is ready to use. The recovered blood retains key leukocyte populations and cell surface markers, ready for high-quality downstream applications including immunophenotyping, PBMC isolation, and functional assays.
Preserve your whole blood sample for up to 3 days
Allows flexible transportation, processing and analysis
Preserve leukocyte populations & cellular markers without fixation or cryopreservation
CytoStor™
Suitable for suspended or adherent cells, viruses, viral vectors & mRNA-LNPs
Cells are mixed with a gel solution, then added to a vial containing gelation beads. After waiting a few minutes, the gel will cure in situ, encapsulating the cells. The vial is sealed and ready for storage or shipment. When ready to be used, a gentle Dissolution Buffer is added to dissolve the gel. Cells can then be sedimented, resuspended and placed in culture.
Stabilise primary & cryosensitive cells for up to 2 weeks
Maintain viability, phenotype & function throughout transport
Highly scalable & automatable
LeukoStor™
Specially formulated for leukapheresis material in vials or blood bags
Mix a gel concentrate with leukapheresis material and transfer to a vial or bag containing gelation beads. After a few minutes, the apheresis material will gel in situ and is ready for storage or shipment. When ready to be used, a gentle Dissolution Buffer is added to dissolve the gel, the beads are filtered out and the apheresis material is ready to use. With Atelerix's bag-based products, components are simply transferred via a transfer line.
Preserve your leukopheresis material for up to 5 days
Maintain viability, phenotype & function of key immune cell populations
Reduces yield variability for greater downstream consistency
Increase geographical flexibility for cell & gene therapy manufacture
Can be handled in a closed system
STORganoid™
Designed for the encapsulation of organoids and spheroids in a vial format
Organoids or spheroids suspended in medium are mixed with a gel solution and then added to a vial containing gelation beads. After waiting for a few minutes, the gel will cure, encapsulating the cells in situ. The vial is sealed and ready for hypothermic storage or shipment. When ready to be used, a gentle Dissolution Buffer is added to dissolve the gel. Organoids can be separated using your standard process before being placed in culture.
Preserve organoids and spheroids at ambient temperature for up to 10 days
Ship ready-to-use organoids and spheroids worldwide
Maintain performance, reproducibility, and scientific integrity
TissueReady PLUS™
Designed for the encapsulation of small tissues, biopsies and tissue resections
To encapsulate your sample, simply add the "ready-mixed" gel solution to a vial containing gelBase beads. Immediately insert your sample and wait a few minutes for the gel to form. It is then ready for storage or shipment. To release, simply add a gentle dissolution buffer, wait a few minutes and your sample can be retrieved and is ready to use.
TissueReady PLUS includes a ready-to-use gel, pre-diluted with a recommended medium for optimal tissue preservation.
Get a 5x extension to fresh tissue shelf life
Increase the quality and yield of viable cells from your tissues
Transport tissues for histological and molecular analyses
Samples can be used fresh or fixed/frozen for long term storage
Clinical sample collection without the need to freeze
TissueReady™
Designed for the encapsulation of organoids, spheroids, microtissues & other tissues
To encapsulate your sample, simply add the gel solution diluted with your medium of choice to a vial containing gelation beads. Immediately insert your sample and wait a few minutes for the gel to form. It is then ready for storage or shipment. To release, simply add a gentle dissolution buffer, wait a few minutes and your sample can be retrieved and is ready to use.
Organoids & spheroids
Organoids or spheroids suspended in medium are mixed with a gel solution and then added to a vial containing gelation beads. After waiting for a few minutes, the gel will cure, encapsulating the cells in situ. The vial is sealed and ready for hypothermic storage or shipment. When ready to be used, a gentle Dissolution Buffer is added to dissolve the gel. Organoids can be separated using your standard process before being placed in culture.
Preserve your fresh tissues, organoids and microtissues for up to 1 week
Increase the quality and yield of viable cells from your tissues
Field-based collection and transport of tissue biopsies
Preservation of organoids and spheroids for research
Storage of microtissues for downstream analysis
WellReady™
Suitable for cells, organoids and microtissues in multi-well plates
With cells, organoids or tissue models in place, three layers of a gel solution are pipetted into each well and cured using a Gelation Buffer. These gel layers offer physiochemical and mechanical protection during hypothermic storage and shipment. When plates are ready to be used, a gentle Dissolution Buffer is added to each well to dissolve the gels. The plates are returned to culture conditions and, once recovered, they are ready to be used for downstream assays or continued culture.
Modified WellReady™ formulations for air-sensitive cells and cardiomyocytes are available, as well as cells grown in culture inserts.
Preserve your cell monolayers and complex 3D models in a range of plate formats
Transport assay-ready plates between research facilities
Physically protect your fragile models during shipping