Applied Biological Materials (abm)

Human Primary Hair Follicle Dermal Papilla Cells

Product Code:
 
ABM-T4059
Product Group:
 
Primary Cells
Cell System:
 
Hair Cell System
Cell Type:
 
Hair cells
Species:
 
Human
Regulatory Status:
 
RUO
 

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ABM-T40595x10? cells / 1.0 mlEnquire
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Further Information

Description:
Human Hair Follicle Dermal Papilla cells are highly active mesenchymal cells isolated from the hair papilla embedded in extracellular matrix of scalp hair follicles. Dermal Papilla Cells play a significant role in controlling the hair growth cycle and production by involving in the epithelial-mesenchymal interaction of hair follicle cells. Their survival is regulated by signal transduction pathways such as ERK and Akt. These cells can be used for development and evaluation of hair growth products and identifying cell populations within the hair follicle. In addition, they can be used for in vitro screening of androgen blocking reagents since they have androgen receptors.
Donor History:
Normal tissue
Growth Conditions:
PriCoat™ ECM T25 Flasks (G999) or Applied Cell Extracellular Matrix (G422) are required for cell adhesion to the culture vessels. PriGrow X Series Medium (TM4059) + 1% Penicillin/Streptomycin Solution (G255), 37.0°C, 5% CO2.
Growth Properties:
Adherent, multipolar
Seeding Density (/cm^2):
6,000 - 10,000
Tissue:
Hair Follicle

References

Kim, Y. E., Choi, H. C., Lee, I. C., Yuk, D. Y., Lee, H., & Choi, B. Y. (2016). 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. Biomolecules & therapeutics, 24(6), 572?580. https://doi.org/10.4062/biomolther.2016.183 Petpiroon, N., Bhummaphan, N., Tungsukruthai, S., Pinkhien, T., Maiuthed, A., Sritularak, B., & Chanvorachote, P. (2019). Chrysotobibenzyl inhibition of lung cancer cell migration through Caveolin-1-dependent mediation of the integrin switch and the sensitization of lung cancer cells to cisplatin-mediated apoptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 58, 152888. https://doi.org/10.1016/j.phymed.2019.152888 Rattanachitthawat, N.. "Development and optimization of finasteride-loaded microemulsions for transdermal delivery" (Doctoral thesis). Silpakorn University Bangkok:Thailand (2019)Rattanachitthawat, N., Pinkhien, T., Opanasopit, P., Ngawhirunpat, T., & Chanvorachote, P. (2019). Finasteride Enhances Stem Cell Signals of Human Dermal Papilla Cells. In vivo (Athens, Greece), 33(4), 1209?1220. https://doi.org/10.21873/invivo.11592