Applied Biological Materials (abm)

dCas9-TET1CD Lentivirus

Product Code:
ABM-K090
Regulatory Status:
RUO
Shipping:
Dry ice
Storage:
-80°C
1 / 1
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This product comes from: Canada.
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Further Information

Description:
This construct consists of the catalytic domain of Ten-Eleven Translocation dioxygenase 1 (TET1CD) fused to the C-terminus of Cas9 Double Mutant (dCas9). The Cas9 Double Mutant has changes at amino acid positions D10A and H840A which completely inactivate both nuclease and nickase activities; whereas the TET1 domain facilitates the process of demethylation leading to transcriptional up-regulation. By using specific sgRNAs, the dCas9-TET1CD can be targeted to a promoter region allowing for epigenetic control over the expression of almost any gene of interest.