Chemodex

Elobixibat

Product Code:
 
CDX-E0316
Product Group:
 
Other Biochemicals
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term: -20°C
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Chemical Structure
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Chemical Structure

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CodeSizePrice
CDX-E0316-M01010 mg£823.00
Quantity:
CDX-E0316-M02525 mg£1,635.00
Quantity:
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This product comes from: Switzerland.
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  • Further Information
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Further Information

Appearance:
White to off-white powder.
CAS:
439087-18-0
Description:
Elobixibat is an inhibitor of the sodium/bile acid and sulfated solute cotransporter (ASBT), also known as the ileal bile acid transporter (IBAT) which is selective for ASBT over the hepatic sodium/bile acid cotransporter. Oral administration of elobixibat reduces methionine- and choline-deficient diet-induced increases in serum bile acid levels and hepatic inflammation, fibrosis, and cytokine gene expression in a mouse model of non-alcoholic steatohepatitis (NASH). Elobixibat lowers LDL cholesterol, increases serum GLP-1, promotes colon motility, and has the potential to treat metabolic syndrome. Elobixibat can be used to study constipation, dyslipidemia, non-alcoholic hepatitis and liver tumors.
EClass:
32160000
Form:
solid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315-H319-H335
InChi:
InChI=1S/C36H45N3O7S2/c1-4-6-18-36(19-7-5-2)24-39(27-16-12-9-13-17-27)28-20-30(47-3)29(21-31(28)48(44,45)25-36)46-23-32(40)38-34(26-14-10-8-11-15-26)35(43)37-22-33(41)42/h8-17,20-21,34H,4-7,18-19,22-25H2,1-3H3,(H,37,43)(H,38,40)(H,41,42)/t34-/m1/s1
InChiKey:
XFLQIRAKKLNXRQ-UUWRZZSWSA-N
MDL:
MFCD28386301
Molecular Formula:
C36H45N3O7S2
Molecular Weight:
695.89
Package Type:
Vial
Precautions:
P261-P305+P351+P338-P302+P352
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
O=S1(=O)C=2C(N(CC(CCCC)(CCCC)C1)C3=CC=CC=C3)=CC(SC)=C(OCC(N[C@@H](C(NCC(O)=O)=O)C4=CC=CC=C4)=O)C2
Solubility Chemicals:
Soluble in methanol (5mg/ml). Slightly soluble in DMSO (1mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

Documents

References

(1) P.-G. Gillberg, et al.; Gastroenterol. 138, S224 (2010) | (2) A. Acosta & M. Camilleri; Therap. Adv. Gastroenterol. 7, 167 (2014) (Review) | (3) M. Rudling, et al.; BMC Cardiovasc. Disord. 15, 75 (2015) | (4) S. Taniguchi, et al.; Neurogastroenterol. Motil. 30, e13448 (2018) | (5) R. Yamauchi, et al.; Hepatol. Int. 15, 392 (2021) | (6) Y. Sugiyama, et al.; Hepatol. Int. 17, 1378 (2023)