Anti-Human IgA (Clone HP6123) - FITC

IgA is produced by B lymphocytes. IgA is secreted by connective tissue, especially intestinal and respiratory tracts as well as lactating breast tissue. IgA is the major Ig isotype present in extracellular fluids secreted by epithelia and is also present in serum.

0.2 mg/ml

This Fluorescein (FITC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

IgA antibodies protect epithelial surfaces from infection by preventing the attachment of bacteria, viruses, and other pathogens to epithelial cells as well as by neutralizing bacterial toxins at mucosal surfaces1. IgA antibodies also provide protection against infection in newborns via the ingestion of breast milk, into which IgA is naturally secreted. IgA can also act as an opsonin and weak complement activator as part of the immune defense response. IgA-secreting plasma cells are found in lamina propria, a type of connective tissue located immediately below the basement membrane of surface epithelia1. Once secreted, IgA antibodies are transported to the external surface of the epithelium as a dimer, where they bind to the poly- Ig receptor present on the basolateral surface of epithelial cells. Transcytosis and cleavage of the receptor then occur, which releases the extracellular portion of the Ig receptor while still attached to the Fc region of IgA. This molecule can then diffuse into the extracellular space and drain into the bloodstream.

Human Immunoglobulin, IgA