Leinco Technologies

Anti-Human IgA (Clone HP6123) - Purified No Carrier Protein

Product Code:
 
LEI-I-1261
Product Group:
 
Secondary Antibody
Host Type:
 
Mouse
Antibody Clonality:
 
Secondary Antibody
Antibody Clone:
 
HP6123
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Flow Cytometry
  • Immunoprecipitation (IP)
Shipping:
 
2-8°C Wet Ice
Storage:
 
This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at < -70°C.Avoid Repeated Freeze Thaw Cycles.
 

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CodeSizePrice
LEI-I-1261-500ug500 ug£319.00
Quantity:
LEI-I-1261-1.0mg1 mg£516.00
Quantity:
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This product comes from: United States.
Typical lead time: 14-21 working days.
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Further Information

Antigen Distribution:
IgA is produced by B lymphocytes. IgA is secreted by connective tissue, especially intestinal and respiratory tracts as well as lactating breast tissue. IgA is the major Ig isotype present in extracellular fluids secreted by epithelia and is also present in serum.
Concentration:
≥1.0 mg/ml
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Product Description:
IgA antibodies protect epithelial surfaces from infection by preventing the attachment of bacteria, viruses, and other pathogens to epithelial cells as well as by neutralizing bacterial toxins at mucosal surfaces1. IgA antibodies also provide protection against infection in newborns via the ingestion of breast milk, into which IgA is naturally secreted. IgA can also act as an opsonin and weak complement activator as part of the immune defense response. IgA-secreting plasma cells are found in lamina propria, a type of connective tissue located immediately below the basement membrane of surface epithelia1. Once secreted, IgA antibodies are transported to the external surface of the epithelium as a dimer, where they bind to the poly- Ig receptor present on the basolateral surface of epithelial cells. Transcytosis and cleavage of the receptor then occur, which releases the extracellular portion of the Ig receptor while still attached to the Fc region of IgA. This molecule can then diffuse into the extracellular space and drain into the bloodstream.
Target:
Human Immunoglobulin, IgA