ROCK Inhibitor Y-27632 is a potent and selective small molecule inhibitor of Rho-associated coiled-coil containing protein kinase (ROCK). It is commonly used in cell culture to promote cell survival, enhance cell proliferation, and maintain the undifferentiated state in various cell types, particularly in stem cell research and tissue engineering applications.
Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II. It also prevents apoptosis induced by isolation in mouse prostate stem or progenitor cells.
| Chemical Properties |
| Molecular Weight |
247.34 |
| Formula |
C14H21N3O |
| Cas No. |
146986-50-7 |
| Relative Density |
1.136 g/cm3 |
| Solubility |
- H2O: insoluble
- 10% DMSO+90% Saline: 2.47 mg/mL (9.99 mM). For In vivo, add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
- DMSO: 45 mg/mL (181.94 mM)
|
