Bioviotica

Benadrostin

Product Code:
BVT-0079
Supplier:
Bioviotica
Regulatory Status:
RUO
Shipping:
Ambient
Storage:
Short term: +4°C. Long term: -20°C
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Chemical Structure
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Chemical Structure

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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
8-Hydroxy-2H-1,3-benzoxazine-2,4(3H)-dione
Appearance:
White to off-white solid.
CAS:
117241-60-8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.
Hazards:
H302, H312, H319
InChi:
InChI=1S/C8H5NO4/c10-5-3-1-2-4-6(5)13-8(12)9-7(4)11/h1-3,10H,(H,9,11,12)
InChiKey:
BQIRLGRTNUTGAT-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 117241-60-8. Formula: C8H5NO4. MW: 179.1. Isolated from Streptomyces rubiguiosohelvolus G?66. Poly(ADP-ribose) polymerase (PARP) inhibitor.
MDL:
MFCD00873726
Molecular Formula:
C8H5NO4
Molecular Weight:
179.1
Package Type:
Plastic Vial
Precautions:
P270, P280, P301, P312, P302, P352, P312
Product Description:
Poly(ADP-ribose) polymerase (PARP) inhibitor.
Purity:
>98% (HPLC; NMR)
Signal word:
Warning
SMILES:
OC1=CC=CC2=C1OC(=O)NC2=O
Solubility Chemicals:
Soluble in DMSO, methanol or chloroform.
Source / Host:
Isolated from Streptomyces rubiguiosohelvolus G?66.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.

References

Benadrostin, new inhibitor of poly(ADP-ribose) synthetase, produced by actinomycetes. I. Taxonomy, production, isolation, physicochemical properties and biological activities: T. Aoyagi, et al.; J. Antibiot. 41, 1009 (1988) | Benadrostin, new inhibitor of poly(ADP-ribose) synthetase, produced by actinomycetes. II. Structure determination: S. Yoshida, et al.; J. Antibiot. 41, 1015 (1988) | Effects of benadrostin, a poly(ADP-ribose) polymerase inhibitor, on apoptosis of HL-60 induced by 5-azacytidine: H. Tobe, et al.; Biosci. Biotechnol. Biochem. 61, 1603 (1997) | New potent DPPH radical scavengers from a marine-derived actinomycete strain USF-TC31: Y. Sugiyama, et al.; Biosci. Biotechnol. Biochem. 73, 2731 (2009)