ProSci

SARS-CoV-2 (COVID-19) Omicron Variant Spike S1 (His-Avi Tag) Recombinant Protein

Product Code:
PSI-95-129
Product Group:
Recombinant Proteins
Supplier:
ProSci
Host Type:
HEK 293 cells
Regulatory Status:
RUO
Target Species:
SARS-CoV-2
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • SDS-PAGE
  • Western Blot (WB)
Product Types:
  • Microbial and Virus Specific
  • Tagged
Shipping:
Dry Ice
Storage:
Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
 

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Further Information

Additional Names:
S protein RBD, Spike glycoprotein Receptor-binding domain, S glycoprotein RBD, Spike protein RBD, Delta variant spike RBD
Application Note:
This recombinant protein can be used for WB and ELISA. For research use only.
Background:
SARS-CoV-2 Omicron variant, a variant of concern (VOC), known as B.1.1.529, was detected in South Africa at the end of November in 2021. However, it rapidly spread all over of the world and now it is the dominant variant in the world, which account for more than 90% of the new cases. Omicron variant spike protein carries around 30 amino acid changes, including mutations, deletions and insertions, in which the receptor binding domain (RBD) protein contains 15 mutations. Enhanced transmission of the Omicron variant was observed globally, which is at least 70 times more contagious than the other variants. The Omicron variant affects the effectiveness of COVID-19 vaccine and is resistant to neutralization (monoclonal antibody treatments) to a large extent.
Background References:
  • Gowrisankar et al. European Physical Journal Plus, 2022, 137(1), 100.
  • Zhang et al. PNAS of U.S.A. 2021, 118(47):e2109905118.
  • Cameroni et al. Nature 2021.
  • Rossler et al. NEJM 2022.
  • Muik et al. Science 2022
Buffer:
PBS (pH 7.4).
Fusion Tag:
His-Avi tag at C-terminus
NCBI Gene ID #:
43740578
NCBI Official Name:
Surface glycoprotein
NCBI Official Symbol:
S
NCBI Organism:
Severe acute respiratory syndrome coronavirus 2
Physical State:
Liquid
Predicted Molecular Weight:
120 kD
Protein Accession #:
QHD43416.1
Purity:
> 90% as determined by Bis-Tris PAGE
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P0DTC1

Documents