iXCells Biotechnologies

Human Motor Neurons (iPSC-derived Normal)

Product Code:
 
IXC-40HU-005
Product Group:
 
iPSC Derived Cells
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Cell Culture
Shipping:
 
dry ice
Storage:
 
Liquid nitrogen
1 / 2
2 / 2
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
IXC-40HU-005-1M1 million cells/vial£766.00
Quantity:
IXC-40HU-005-2M2 million cells/vial£1,375.00
Quantity:
IXC-40HU-005-4M4 million cells/vial£2,279.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges to UK mainland customers, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Related Products
  • Show All

Further Information

Cell Type:
Neural
Disease:
Normal
PMID:
36043141; 35017408; 33558503; 31151992; 30853299; 30825670; 30643298; 29235536; 28594877
Short Description:
iPSC-derived Motor Neurons. Express HB9, ISL1, ChAT. 65% exhibit mature spiking; 35% display spontaneous activity. Suitable for neuromuscular disease models and drug discovery.

References

  • PubMed ID: 36043141 Wong, J. K., Roselle, A. K., Shue, T. M., Shimshak, S. J., Beaty, J. M., Celestin, N. M., Gao, I., Griffin, R. P., Cudkowicz, M. E., & Sadiq, S. A. (2022). Apolipoprotein B-100-mediated motor neuron degeneration in sporadic amyotrophic lateral sclerosis. Brain Communications, 4(4). https://doi.org/10.1093/braincomms/fcac207 ? Learn More
  • PubMed ID: 35017408 Liu B, Li M, Zhang L, Chen Z, Lu P. (2022). Motor neuron replacement therapy for amyotrophic lateral sclerosis. Neural Regen Res;17:1633-9 ? Learn More
  • PubMed ID: 33558503 Liu, Y., Dodart, J., Tran, H., Berkovitch, S., Braun, M., Byrne, M., . . . Brown, R. H. (2021). Variant-selective stereopure oligonucleotides protect against pathologies associated with c9orf72-repeat expansion in preclinical models. Nature Communications, 12(1). doi:10.1038/s41467-021-21112-8 ? Learn More
  • PubMed ID: 31151992 Shen, X., Beasley, S., Putman, J. N., Li, Y., Prakash, T. P., Rigo, F., . . . Corey, D. R. (2019). Efficient electroporation of neuronal cells using synthetic oligonucleotides: Identifying duplex RNA and antisense oligonucleotide activators of Human frataxin expression. RNA, 25(9), 1118-1129. doi:10.1261/rna.071290.119 ? Learn More
  • PubMed ID: 30853299 Gasset-Rosa, F., Lu, S., Yu, H., Chen, C., Melamed, Z., Guo, L., . . . Cleveland, D. W. (2019). Cytoplasmic TDP-43 de-mixing independent of stress granules drives inhibition of nuclear import, loss of nuclear TDP-43, and cell death. Neuron, 102(2). doi:10.1016/j.neuron.2019.02.038 ? Learn More
  • PubMed ID: 30825670 Martier, R., Liefhebber, J. M., Garc?a-Osta, A., Miniarikova, J., Cuadrado-Tejedor, M., Espelosin, M., . . . Konstantinova, P. (2019). Targeting rna-mediated toxicity in c9orf72 als and/or ftd by rnai-based gene therapy. Molecular Therapy ? Nucleic Acids, 16, 26-37. doi:10.1016/j.omtn.2019.02.001 ? Learn More
  • PubMed ID: 30643298 Melamed, Z., L?pez-Erauskin, J., Baughn, M. W., Zhang, O., Drenner, K., Lin, N., Wu, D., . . . Cleveland, D. W. (2019). Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of tdp-43-dependent neurodegeneration. Nature Neuroscience, 22(2), 180-190. doi:10.1038/s41593-018-0293-z ? Learn More
  • PubMed ID: 29235536 Marei, H. E., Althani, A., Lashen, S., Cenciarelli, C., & Hasan, A. (2017). Genetically unmatched human Ipsc and Esc Exhibit Equivalent gene expression and neuronal differentiation potential. Scientific Reports, 7(1). doi:10.1038/s41598-017-17882-1 ? Learn More
  • PubMed ID: 28594877 Danziger, S. A., Miller, L. R., Singh, K., Whitney, G. A., Peskind, E. R., Li, G., . . . Smith, J. J. (2017). An indicator cell assay for blood-based diagnostics. PLOS ONE, 12(6). doi:10.1371/journal.pone.0178608 ? Learn More