TargetMol

WWL123

Product Code:
 
TAR-T22171
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22171-5mg5mg£78.00
Quantity:
TAR-T22171-10mg10mg£97.00
Quantity:
TAR-T22171-25mg25mg£151.00
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TAR-T22171-50mg50mg£200.00
Quantity:
TAR-T22171-100mg100mg£265.00
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This product comes from: Austria.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
WWL123 is a potent and selective ABHD6 inhibitor (IC50=430 nM). WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by WWL123 exerts an antiepileptic effect in Pentylenetetrazole (PTZ)-induced epileptiform seizures and spontaneous seizures in R6/2 mice.
CAS:
1338575-41-9
Formula:
C28H24N2O3
Molecular Weight:
436.5
Pathway:
Metabolism
Purity:
0.9944
SMILES:
O=C(N)C=1C=CC(=CC1)C2=CC=CC(OC(=O)N(C)CC3=CC=CC(=C3)C=4C=CC=CC4)=C2
Target:
MAGL

Documents

References

1. Daniel A Bachovchin, et al. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20941-6. 2. Peng Zhong, et al. Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. J Physiol. 2011 Oct 15;589(Pt 20):4847-55. 3. Alipi V Naydenov, et al. ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron. 2014 Jul 16;83(2):361-371.