TargetMol

CGP77675

Product Code:
 
TAR-T30855
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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This product comes from: Austria.
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Further Information

Bioactivity:
CGP77675 is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and autophosphorylation of purified Src. CGP77675 exhibits anticancer activity.
CAS:
234772-64-6
Formula:
C26H29N5O2
Molecular Weight:
443.54
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis; JAK/STAT signaling; Cytoskeletal Signaling
Purity:
0.9823
SMILES:
OC1CCN(CCC2=CC=C(C=C2)N3C=C(C=4C=CC=C(OC)C4)C=5C(=NC=NC53)N)CC1
Target:
EGFR; VEGFR; Bcr-Abl; Src

Documents

References

1. Breitenlechner CB, et al. Crystal structures of active SRC kinase domain complexes. J Mol Biol. 2005 Oct 21;353(2):222-31. 2. Zhang Q, et al. Inhibition of Src kinases combined with CD40 ligand blockade prolongs murine cardiac allograft survival. Transplantation. 2005 Oct 27;80(8):1112-20. 3. Missbach M, et al. A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellularsubstrates and reduces bone resorption in vitro and in rodent models in vivo. Bone. 1999 May;24(5):437-49.