TargetMol

Bcl-xL antagonist 2

Product Code:
 
TAR-T38622
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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This product comes from: Austria.
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Further Information

Bioactivity:
Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic leukemia and non-Hodgkin?s lymphoma.
CAS:
1235032-75-3
Formula:
C21H16N4O3S2
Molecular Weight:
436.51
Pathway:
Apoptosis
Purity:
0.9813
SMILES:
O=C(O)C=1N=C(SC1)N2CC=3C(=CC=CC3CC2)C(=O)NC4=NC=5C=CC=CC5S4
Target:
BCL

Documents

References

Koehler MF, et al. Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL. ACS Med Chem Lett. 2014;5(6):662-667. Wang L, et al. Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor. ACS Med Chem Lett. 2020;11(10):1829-1836.