TargetMol

GNE-6640

Product Code:
 
TAR-T5461
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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This product comes from: Austria.
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Further Information

Bioactivity:
GNE-6640 is a non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP43 and Ub-MDM2, respectively.
CAS:
2009273-67-8
Formula:
C20H18N4O
Molecular Weight:
330.391
Pathway:
Ubiquitination; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.9959
SMILES:
CCc1c(cnc(N)c1-c1ccc(O)cc1)-c1ccc2[nH]ncc2c1
Target:
DUB

Documents

References

Kategaya L, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550(7677):534-538.