IQ Products

Phosphatidyl Serine Detection Kit: Complete kit containing: Annexin V, propidium iodide and calcium buffer

Product Code:
 
IQP-116R
Product Group:
 
Cell Based Assays
Supplier:
 
IQ Products
Regulatory Status:
 
RUO
Application:
 
Flow Cytometry
 

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IQP-116Rkit for 100 test£524.00
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  • Further Information
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Further Information

Applications:
  • Monitor cell death is important in a wide variety of clinical situations
  • Frequent application is monitoring cell death during tumor therapy
  • For research only. Not for use in humans
Category:
Detection of Apoptosis
Description / cellular expression:
Complete kit containing: Annexin V, propidium iodide and calcium buffer
Features:
  • Rapid and reliable method for detection of apoptosis
  • Flow cytometry test
  • Detection at single cell level
  • Distinction between apoptosis and necrosis
Introduction:
Apoptosis or programmed cell death (PCD) is a genetically encoded cell elimination program which ensures an equilibrium between cell proliferation and cell death and by which damaged or unwanted cells are eliminated. Therefore it is important to stress that apoptosis is a normal physiological process. Without continuous signaling by growth factors, hormones or cytokines, all cells undergo PCD. Aberrations in the mechanism of apoptosis occur in congenital defects, malignancies, auto-immune diseases, immune deficiency syndromes and in degenerative conditions.
Label:
R-PE

References

  1. Green, D.R., and Martin, S.J., 1995. The killer and the executioner: how apoptosis controls malignancy. Curr.opin. Immunol. 7: 694-703
  2. Jacobson, M.D., 1997. Programmed cell death in animal development. Cell 88: 347-354
  3. Vermes et al. 1995. A novel assay for apoptosis: Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V. J. Immunol. Methods. 184. 39-51
  4. Martin, S.J., et al., 1995. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus. Inhibition by over expression of Bcl-2 and Abl.. J.Exp. Med. 182, 1545 ? 1557
  5. Koopman et al. 1994. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood. 84, 1415-1420