Leinco Technologies

UltraAvidin™ Purified

Product Code:
 
LEI-A110
Product Group:
 
Other Proteins
Host Type:
 
Chicken
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
The lyophilized UltraAvidin? should be stored desiccated at -20°C. Store reconstituted UltraAvidin? at -20°C in working aliquots. Avoid repeated freezing and thawing.
 

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This product comes from: United States.
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Further Information

Conjugate/Tag/Label:
Purified
Format:
UltraAvidin™ is lyophilized from a salt-free solution.
Formulation:
UltraAvidin™ is lyophilized from a salt-free solution.
Long Description:
UltraAvidin™ is Leinco Technologies' trademark for a uniquely modified form of avidin which is isolated from chicken egg whites. With a molecular weight of 60,000, there are four identical subunits each capable of binding one molecule of biotin. UltraAvidin from Leinco Technologies has been de-glycosylated to prevent carbohydrate moieties from adhering to lectin-like receptors on the surface of cells, thus eliminating the possibility of false positives. Unlike native avidin, UltraAvidin has a near neutral pI which prevents electrostatic interactions with negatively charged serum or membrane proteins. Recent studies have identified a universal recognition sequence in streptavidin which is similar to that found in several adhesion receptors.(1) It is a tripeptide sequence Arg-Tyr-Asp (RYD) which mimics the Arg-Gly-Asp (RGD) binding sequence of fibronectin. Strong interactions have been shown with streptavidin and cell surface molecules. This universal recognition sequence is not present in UltraAvidin. UltraAvidin may not significantly increase sensitivity in all research systems but will help assure specificity.

References

1. Wilchek, M. et al.(1990) Biochem Biophys Res Commun. 1990 170(3):1236-41.