Leinco Technologies

Mouse TNFα Antibody - Purified in vivo GOLD™ Functional Grade

Product Code:
LEI-T258
Product Group:
Primary Antibodies
Host Type:
Hamster
Antibody Isotype:
IgG
Antibody Clonality:
Monoclonal
Antibody Clone:
TN3-19.12
Regulatory Status:
RUO
Target Species:
Mouse
Applications:
  • Immunoprecipitation (IP)
  • In Vivo Assay
  • Neutralisation
  • Western Blot (WB)
Product Types:
  • Cytokines and Other Signalling
  • in vivo
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
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Further Information

Antigen Distribution:
Activated monocytes, neutrophils, macrophages, T cells, B cells, NK cells, LAK cells
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Recombinant mouse TNFα
Long Description:
The tumor necrosis factor (TNF-alpha) is a multifaceted polypeptide cytokine known as a mediator of inflammation and immunity.1 It may mediate some of the significant changes in cellular homeostasis which accompany the invasion of the mammalian host by viruses, bacteria, and parasites.2 TNF-α is an acute phase protein which initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophage and neutrophils to a site of infection. TNF-α secreted by the macrophage causes blood clotting which serves to contain the infection. TNF-α has been detected in synovial fluid of patients with rheumatoid arthritis. Clone TN3-19.12 antibody can neutralize the bioactivity of natural or recombinant TNF-α
NCBI Gene:
21926
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
Tumor Necrosis Factor-Alpha

References

1.) El-Harith el-HA et al. (2004) Saudi Med J. 25: 135 2.) Adolf GR et al. (1990) Infec Immun. 58: 3996 3.) Czepielewski, R. et al. (2021) Immunity 54(12):2795-2811.e9 Journal Link