Leinco Technologies

Anti-Human CD11a - DyLight® 755

Product Code:
LEI-C1716
Product Group:
Primary Antibodies
Host Type:
Mouse
Antibody Isotype:
IgG2a
Antibody Clonality:
Monoclonal
Antibody Clone:
38
Regulatory Status:
RUO
Target Species:
Human
Application:
Flow Cytometry
Shipping:
2-8°C
Storage:
This DyLight® 755 conjugate is stable when stored at 2-8°C. Do not freeze.
 

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Further Information

Antigen Distribution:
CD11a is present on thymocytes, blood lymphocytes, bone marrow cells and certain lymphoma and macrophage-like cell lines.
Concentration:
0.1 mg/ml
Conjugate/Tag/Label:
DyLight® 755
Format:
This DyLight® 755 conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This DyLight® 755 conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen:
Purified Recombinant Human CD11a (>98%)
Long Description:
LFA-1α (CD11a) and CD18 are the Integrin alpha-L and beta-2 chains respectively that combine to form LFA-1, a glycoprotein and a member of the Integrin family. Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3, ICAM4 and for F11R. LFA-1 participates in the immunological synapses between CD8+ T lymphocytes and antigen-presenting cells. The absence of LFA-1α or β may induce LAD. The antigen contributes to natural killer cell cytotoxicity, and is involved in various immune phenomena such as leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. The CD11b/CD18 antigen is a heterodimeric surface glycoprotein on leukocytes and belongs to the β2 integrin family. CD11b functions as a receptor for C3bi complement, clotting factor X, fibrinogen and ICAM-1. CD11c forms an α/β heterodimeric glycoprotein (CD11c/CD18 complex) which belongs to the β2 integrin family. The complex binds fibrinogen and reportedly serves as a receptor for iC3b and ICAM-1. During inflammatory responses, it mediates cell to cell interaction and is important in both monocyte adhesion and chemotaxis.
NCBI Gene:
3683
Target:
CD11a

References

1. Dransfield, I. et al. (1989) The EMBO Journal 8:3759