Leinco Technologies

Camptothecin

Product Code:
LEI-C2840
Product Group:
Substrates
Regulatory Status:
RUO
Shipping:
20°C
Storage:
Storage: -20°C
 

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This product comes from: United States.
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Further Information

Long Description:
Camptothecin is a potent cytotoxic pentacyclic alkaloid known for its potent apoptosis inducing properties. Camptothecin and its analogs have been demonstrated to inhibit topoisomerase I (topo I), causing cells in S phase to enter into apoptosis. Camptothecin binds to and stabilizes the topo I ? DNA backbone complex (covalent binary complex). This stabilized complex diminishes the rate of topo I release from the broken strand, thus slowing the religation and subsequent DNA synthesis process. Use camptothecin to create positive controls in apoptosis detection experiments.