Leinco Technologies

Anti-Mouse CTLA-4 (Clone 9H10) - Purified in vivo PLATINUM™ Functional Grade

Product Code:
LEI-C2841
Product Group:
Primary Antibodies
Host Type:
Hamster
Antibody Isotype:
IgG
Antibody Clonality:
Monoclonal
Antibody Clone:
9H10
Regulatory Status:
RUO
Target Species:
Mouse
Applications:
  • Blocking
  • In Vivo Assay
  • Western Blot (WB)
Product Types:
  • Immune Checkpoint
  • in vivo
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
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Further Information

Antigen Distribution:
Activated T cells
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
Purified in vivo Functional Grade, in vivo PLATINUM™
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Mouse CTLA-4-human IgG1 fusion protein
Long Description:
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152, is a protein which is expressed on the surface of Helper T cells and plays an important regulatory role in the immune system.1 CTLA4 is a member of the immunoglobulin superfamily, expressed on the surface of Helper T cells. CTLA4 transmits an inhibitory signal to T cells.2,3 CTLA4 is potentially therapeutic in autoimmune diseases4, such as rheumatoid arthritis, HIV, autoimmune thyroid disease, multiple sclerosis and may also be useful during organ transplantation and cancer treatment. The 9H10 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.
NCBI Gene:
12477
Purity:
?98% monomer by analytical SEC, >95% by SDS Page
Target:
CLTA-4

References

1. Allison JP, et al. 1995. Science 270:932.