TargetMol

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Product Code:
 
TAR-TMPK-01442
Product Group:
 
MHC Tetramers
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TMPK-01442-10ug10 ugEnquire
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TAR-TMPK-01442-100ug100ugEnquire
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TAR-TMPK-01442-20ug20 ugEnquire
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TAR-TMPK-01442-5ug5 ugEnquire
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This product comes from: Austria.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
Purity:
98%

References

1.Donnellan Z, et al. ImmTACs: bi-specific TCR-anti-CD3 fusions for targeted tumour killing[J]. Journal for ImmunoTherapy of Cancer, 2015, 3(Suppl 2):P299.