RevMAb Biosciences

anti-Ki-67 (human), Rabbit Monoclonal (RM521)

Product Code:
REV-31-1413-00
Product Group:
Secondary Antibody
Host Type:
Rabbit
Antibody Isotype:
Rabbit IgG
Antibody Clonality:
Monoclonal
Antibody Clone:
RM521
Regulatory Status:
RUO
Target Species:
Human
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
Blue Ice
Storage:
Short term: +4°C. Long term: -20°C
 

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This product comes from: Switzerland.
Typical lead time: 14-21 working days.
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Further Information

Form:
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A peptide corresponding to the internal region of human Ki-67.
Long Description:
Recombinant Antibody. This antibody reacts to human Ki-67. Isotype: Rabbit IgG. Immunogen: A peptide corresponding to the internal region of human Ki-67. Applications: IHC, WB. Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during the late G1, S, G2, and M phases. The protein has a forkhead-associated domain (FHA) through which it associates with euchromatin at the peri chromosomal layer, the centromeric heterochromatin and the nucleolus. Ki-67 is shown to have a cell cycle-dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2 and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation. In breast cancer, Ki67 identifies a high proliferative subset of patients with ER-positive breast cancer who derive greater benefit from adjuvant chemotherapy.
NCBI, Uniprot Number:
P46013
Package Type:
Vial
Product Description:
Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during the late G1, S, G2, and M phases. The protein has a forkhead-associated domain (FHA) through which it associates with euchromatin at the peri chromosomal layer, the centromeric heterochromatin and the nucleolus. Ki-67 is shown to have a cell cycle-dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2 and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation. In breast cancer, Ki67 identifies a high proliferative subset of patients with ER-positive breast cancer who derive greater benefit from adjuvant chemotherapy.
Purity:
Protein A purified.
Specificity:
This antibody reacts to human Ki-67.
Transportation:
Non-hazardous
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

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