TargetMol

LTGO-33

Product Code:
 
TAR-T84298
Product Group:
 
Other Biochemicals
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T84298-1mL1 mL * 10 mM (in DMSO)Enquire
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TAR-T84298-10mg10mgEnquire
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TAR-T84298-25mg25mgEnquire
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TAR-T84298-50mg50mgEnquire
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TAR-T84298-1mg1mg£79.00
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TAR-T84298-5mg5mg£149.00
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Further Information

Bioactivity:
LTGO-33 is a species-specific inhibitor of the voltage-gated sodium channel NaV1.8, inhibiting NaV1.8, NaV1.1-NaV1.7, and NaV1.9.LTGO-33 inhibits wild-type and multiple NaV1.8 variants associated with human pain disorders and can be used for the study of pain.hBChE-IN-2 is a low affinity Nurr1 agonist.
CAS Number:
2834106-06-6
Formula:
C21H17F4N3O3S
Molecular Weight:
467.44
Pathway:
Membrane transporter/Ion channel
Purity:
98%
SMILES:
C[S@@](C1=CC=CC(NC(C2=C(N=CC(C(F)(F)F)=C2)OC3=C(C=C(C=C3)F)C)=O)=C1)(=N)=O
Target:
Sodium Channel

Documents

References

Gilchrist JM, et al. Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of Action. Mol Pharmacol. 2024 Feb 15;105(3):233-249.