KactusBio Inc.

Chimeric HLA-A*02:01 (ma3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer Protein (MHC-HM106)

Product Code:
 
KAC-MHC-HM106
Product Group:
 
MHC Monomers
Supplier:
 
KactusBio Inc.
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Shipped with dry ice.
Storage:
 
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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HLA-A*02:01&B2M&MAGE-A4 (KVLEHVVRV) TCR immobilized on CM5 Chip can bind Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer, His Tag with an affinity constant of 4.76 uM as determined in SPR assay (Biacore T200)
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Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%
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The purity of Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer is greater than 95% as determined by SEC-HPLC.
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HLA-A*02:01&B2M&MAGE-A4 (KVLEHVVRV) TCR immobilized on CM5 Chip can bind Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer, His Tag with an affinity constant of 4.76 uM as determined in SPR assay (Biacore T200)
Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%
The purity of Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer is greater than 95% as determined by SEC-HPLC.

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CodeSizePrice
KAC-MHC-HM106-100UG100UG£414.00
Quantity:
KAC-MHC-HM106-500UG500UG£1,061.00
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Further Information

Background:
MAGE-A4 and MAGE-A8 are type I membes of the melanoma associated antigen (MAGE) family. The MAGE family is a large, highly conserved group of proteins that share a common MAGE homology domain. Both MAGE-A4 and MAGE-A8 antigen-presenting peptides can be presented by HLA-A*02:01.
Biotinylated:
no
Description:
Recombinant Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Gly25-Thr206 (Human HLA-A*02:01 α1&α2) and Asp207-Glu299 (Mouse H-2Ld α3), Ile21-Met119 (mB2M) and KVLEHVVRV peptide.
Endotoxin:
Less than 1EU per ug by the LAL method.
Exact Sequence:
Gly25-Thr206(Human HLA-A*02:01 α1&α2) & Asp207-Glu299(Mouse H-2Ld α3), Ile21-Met119(mB2M) and KVLEHVVRV peptide
Expression System:
HEK293
Form:
Liquid
Formulation:
Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Gene/Protein ID:
A0A140T913(Human HLA-A*02:01 α1&α2)&P01897(Mouse H-2Ld α3)&&P01887(Mouse B2M)&KVLEHVVRV
Molecular Weight:
The protein has a predicted MW of 48.00 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result.
Purity:
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Tag:
C-His
Target:
HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer

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