KactusBio Inc.

Vaccinia Capping Enzyme GMP-Grade (GMP-VCS-VE101) DMF #038028

Product Code:
KAC-GMP-VCS-VE101
Supplier:
KactusBio Inc.
Regulatory Status:
GMP grade
Shipping:
Shipped with blue ice.
Storage:
-20?5°C for 24 months. Avoid repeated freeze-thaw cycles.
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Figure 1. Analysis of mRNA capping efficiency using LC-MS.
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Figure 1. Analysis of mRNA capping efficiency using LC-MS.

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This product comes from: United States.
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Further Information

Description:
The 7-methylguanosine cap structure (m7Gppp, Cap0) is a specific feature in eukaryotic mRNA, which is required for mRNA stability, splicing, nuclear export, effective translation, and mRNA decay. Vaccinia Capping Enzyme, a heterodimer of D1 and D12 subunits, adding the Cap0 structure to the 5' end of the RNA. The D1 subunit comprises an N-terminal RNA triphosphatase (TPase), a guanylyltransferase (GTase), and a C-terminal guanine-N7-methyltransferase (MTase). The D12 subunit binds and stimulates the MTase.

NOTE: mRNA Cap 2'-O-Methyltransferase (Kactus #GMP-MEH-VE101) is required to generate Cap 1 structure that reduces cellular innate immune response when the RNA is used in vivo .

This product has been filed with the FDA Drug Master Files (DMF) and is assigned DMF #038028.
Formulation:
Liquid

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