AdipoGen Life Sciences

SLU-PP-332 - Research Use Only

Product Code:
 
AG-CR1-3555
Product Group:
 
Other Biochemicals
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term: -20°C
1 / 1
Chemical Structure
❮❯

Chemical Structure

No additional charges, what you see is what you pay! *

CodeSizePrice
AG-CR1-3555-M0055 mg£36.00
Quantity:
AG-CR1-3555-M02525 mg£111.00
Quantity:
AG-CR1-3555-M100100 mg£311.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges to UK mainland customers, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Appearance:
White to off-white solid.
CAS:
303760-60-3
Description:
SLU-PP-332 is a potent and selective pan-estrogen-related receptor (ERR) agonist (EC50 values are 98 nM, 230 nM and 430 nM for ERRalpha, ERRbeta and ERRgamma respectively). SLU-PP-332 increases energy expenditure and fatty acid oxidation, decreases fat mass, and improves insulin sensitivity. It enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 decreases body weight and fat mass, blood levels of total cholesterol, HDL and triglycerides and adipocyte size in a mouse model of high-fat diet-induced obesity when administered at a dose of 50 mg/kg twice per day. It reduces blood glucose levels in a glucose tolerance test in the same animals at the same dose. Estrogen-related receptors ERRalpha and ERRgamma are essential regulators of cardiac metabolism. SLU-PP-332 significantly improved ejection fraction, ameliorated fibrosis and increased survival associated with pressure overload-induced heart failure (HF) without affecting cardiac hypertrophy.
EClass:
32160000
Form:
solid
Formula:
C18H14N2O2
Handling Advice:
Keep cool and dry.
InChi Key:
RNZIMBFHRXYRLL-XDHOZWIPSA-N
MDL:
MFCD00595076
Molecular Weight:
290.3
Package Type:
Vial
Purity Chemicals:
≥98%
Smiles:
O=C(C1=CC=C(O)C=C1)N/N=C/C2=CC3=CC=CC=C3C=C2
Solubility:
Soluble in DMSO (5mg/ml).
Synonyms:
4-Hydroxy-N'-[(E)-2-naphthylmethylene]benzohydrazide
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use/Stability:
Stable for at least 2 years after receipt when stored at -20°C.

Documents

References

Synthetic ERRalpha/beta/gamma Agonist Induces an ERRalpha-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity: C. Billon, et al.; ACS Chem. Biol. 18, 756 (2023) | Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney: X.X. Wang, et al.; Am. J. Pathol. 193, 1969 (2023) | A synthetic ERR agonist alleviates metabolic syndrome: C. Billon, et al.; J. Pharmacol. Exp. Ther. 388, 232 (2024) | Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function: W. Xu, et al.; Circulation 149, 227 (2024)