Elabscience

Caspase 4 Activity Detection Substrate for Flow Cytometry

Product Code:
E-CK-A484
Product Group:
Substrates
Supplier:
Elabscience
Regulatory Status:
RUO
Shipping:
Ice bag
Storage:
This product can be stored at -20°C for 1 year in the dark.
 

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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Assay Time:
30 min
Detection Instrument:
Flow Cytometer;Fluorescence microscope
Detection Type:
Fluorometric method;Flow cytometry
Test Principle:
The Caspase 4 Activity Detection Substrate for Flow Cytometry are a novel fluorogenic dye that couple the caspase 4 recognition sequence (LEVD) to a high affinity DNA dye, which have cell membrane permeability and can penetrate the plasma membrane into the cytoplasm. The substrate itself has no fluorescence and has a charge exclusion effect with DNA. During cell apoptosis, caspase-4 cleaves the substrate and releases high affinity DNA dyes, which bind to DNA to produce strong fluorescence, thereby detecting caspase-4 activity and visualizing the morphological changes of the cell nucleus during apoptosis.
Tested Sample Types:
Cell samples
Type:
Apoptosis/Caspase

Documents