TargetMol

(R)-STU104-d6

Product Code:
 
TAR-T207425
Product Group:
 
Substrates
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
(R)-STU104-d6 is a deuterium-labeled variant of (R)-STU104. This compound acts as a potent and orally active inhibitor of the interaction between TAK1 and MKK3 proteins, exhibiting IC50 values of 0.58 uM for TNF-α and 4.0 uM for MKK3 phosphorylation. By binding to MKK3, (R)-STU104 hinders TAK1's ability to phosphorylate MKK3, thereby disrupting the TAK1/MKK3/p38/MnK1/MK2/elF4E signaling pathway. It is utilized in research related to ulcerative colitis.
CAS Number:
3063042-81-6
Formula:
C18H182D6O4
Molwt:
304.37
Pathway:
MAPK
SMILES:
O(C([2H])([2H])[2H])C1=C2[C@H](CC(=O)C2=CC(OC([2H])([2H])[2H])=C1)C3=CC=C(OC)C=C3
Target:
p38 MAPK

Documents