TargetMol

OncoFAP acetate

Product Code:
 
TAR-T41087L
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T41087L-1mg1 mgEnquire
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Further Information

Bioactivity:
OncoFAP acetate is the highest-affinity small organic fibroblast activation protein (FAP) ligand reported to date, exhibiting a dissociation constant of 680 pM as measured by fluorescence polarization. OncoFAP derivatives, when administered intravenously in both fluorescent and radiolabeled forms, selectively accumulate in FAP-positive tumors while sparing normal tissues, enabling OncoFAP acetate to serve as modular components for targeted therapeutic delivery of radionuclides, CAR-T cells, or cytotoxic agents in oncology studies.
Formula:
C108H174N36O22S.xC2H4O2
Molwt:
2360.87 (free base)
Pathway:
Immunology/Inflammation
Purity:
0.99873
SMILES:
OC(CNC(CNC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H](CCCCN)NC([C@H](CCSC)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
Target:
Immunology/Inflammation related

Documents

References

Liu C, et al. Penetratin, a potentially powerful absorption enhancer for noninvasive intraocular drug delivery. Mol Pharm. 2014 Apr 7;11(4):1218-27.