TargetMol

Pemetrexed disodium heptahydrate

Product Code:
 
TAR-T66032
Product Group:
 
Other Biochemicals
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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This product comes from: Austria.
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Further Information

Bioactivity:
Pemetrexed disodium heptahydrate (LY231514) is an antifolate that inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinyl-adenosine 5'-monophosphate (GARMT) with K_i values of 1.3 nM, 7.2 nM, and 65 nM respectively. This inhibits the formation of precursor purine and pyrimidine nucleotides and cancer cell proliferation, making it suitable for research into pleural mesothelioma and non-small cell lung cancer (NSCLC).
CAS Number:
357166-29-1
Formula:
C20H33N5Na2O13
Molwt:
597.49
Pathway:
Autophagy|Metabolism|DNA Damage/DNA Repair|Cell Cycle/Checkpoint
Purity:
0.99783
SMILES:
O.O.O.O.O.O.O.[Na+].[Na+].Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)NC(CCC([O-])=O)C([O-])=O)c[nH]c2[nH]1
Target:
Antifolate|DNA/RNA Synthesis|DHFR|Autophagy

Documents