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Further Information
Bioactivity:
Exenatide acetate is a polypeptide hormone composed of 39 amino acids. As a glucagon-like peptide-1 (GLP-1) receptor agonist with an IC50 of 3.22 nM, it is indicated for the treatment of insulinoma and type 2 diabetes. Exendin acetate promotes migration, sprouting, and nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs) in vitro. It exhibits cytotoxicity towards MCF-7 cells and provides protective effects against ischaemic injury in a mouse hindlimb model.
