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8-bromo NAD+ sodium

Product Code:
 
TAR-T83798
Product Group:
 
Other Biochemicals
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
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This product comes from: Austria.
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Further Information

Bioactivity:
8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38. At a concentration of 1 mM, it effectively inhibits the rise in intracellular calcium levels and chemotaxis triggered by N-formyl-Met-Leu-Phe (fMLP) in mouse bone marrow-derived neutrophils. Furthermore, when applied at 100 uM, this compound reduces LPS-induced nitrite production and decreases the secretion of TNF-α and IL-2 in mouse primary microglial cells.
CAS Number:
2022926-16-3
Formula:
C21H25BrN7O14P2.Na
Molwt:
764.3
Pathway:
Membrane transporter/Ion channel|Metabolism|
SMILES:
O[C@H]([C@@H]([C@H](O1)COP([O-])(OP([O-])(OC[C@H]([C@H]([C@H]2O)O)O[C@H]2[N+]3=CC(C(N)=O)=CC=C3)=O)=O)O)[C@@H]1N4C5=NC=NC(N)=C5N=C4Br.[Na+]
Target:
|Calcium Channel