TargetMol

Ageladine A dihydrochloride

Product Code:
 
TAR-TN8932
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
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Further Information

Bioactivity:
Ageladine A dihydrochloride, derived from the marine sponge Agelas nakamurai, serves as a matrix metalloproteinase (MMP) inhibitor with anti-angiogenic properties. It inhibits MMP-2, MMP-1, MMP-8, MMP-9, MMP-12, and MMP-13, with IC50 values of 4.65 uM, 2.79 uM, 907.12 nM, 1.83 uM, 767.57 nM, and 1.09 uM, respectively. As a pH-sensitive membrane-permeable dye, it emits fluorescence in the blue-green range when excited by ultraviolet light, with a maximum absorption peak at 370 nm. Additionally, Ageladine A dihydrochloride is used as a reliable and stable fluorescent pH sensor to detect intracellular pH changes.
CAS Number:
2757574-06-2
Formula:
C10H9Br2Cl2N5
Molwt:
429.926
Pathway:
Proteases/Proteasome
SMILES:
BrC1=C(Br)NC(C2=NC=CC3=C2N=C(N)N3)=C1.Cl.Cl
Target:
MMP

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