TargetMol

4, 4'-Secalonic acid D

Product Code:
 
TAR-TN9010
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TN9010-10mg10 mgEnquire
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TAR-TN9010-50mg50 mgEnquire
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This product comes from: Austria.
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Further Information

Bioactivity:
4,4'-Secalonic acid D (Compound 12) is a PARP1 inhibitor. By inhibiting PARP1, 4,4'-Secalonic acid D induces the accumulation of ROS and DNA damage, activating the caspase-3/GSDME pathway, which leads to tumor cell apoptosis (apoptosis) and pyroptosis (pyroptosis). It exhibits antitumor activity.
CAS Number:
2265910-52-7
Formula:
C32H30O14
Molwt:
638.572
Pathway:
Proteases/Proteasome|Apoptosis|DNA Damage/DNA Repair|Chromatin/Epigenetic|Metabolism|NF-κB|Immunology/Inflammation
SMILES:
C(OC)(=O)[C@]12C(C(=O)C=3C(O1)=C(C=CC3O)C4=C5C(C(=O)C=6[C@@](C(OC)=O)(O5)[C@H](O)[C@@H](C)CC6O)=C(O)C=C4)=C(O)C[C@H](C)[C@H]2O
Target:
Caspase|Pyroptosis|Apoptosis|PARP|Reactive Oxygen Species

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