TargetMol

Siphonaxanthin

Product Code:
 
TAR-TN9850
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
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TAR-TN9850-10mg10 mgEnquire
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TAR-TN9850-50mg50 mgEnquire
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This product comes from: Austria.
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Further Information

Bioactivity:
Siphonaxanthin is a carotenoid found in green algae, known for targeting the death receptor 5 (DR5) on cancer cells to induce apoptosis. In human leukemia HL-60 cells, it increases DR5 expression, reduces Bcl-2 levels, and activates caspase-3. It also inhibits fibroblast growth factor receptor-1 (FGFR-1) signaling in endothelial cells. Siphonaxanthin suppresses the proliferation, migration, and tubular formation of human umbilical vein endothelial cells (HUVECs), as well as the growth of microvessels in rat aorta rings. Additionally, it has anti-inflammatory properties by blocking the translocation of high-affinity IgE receptors (FcεRI) to lipid rafts in mast cells. Siphonaxanthin shows potential for research into diseases such as cancer, diabetic retinopathy, and rheumatoid arthritis.
CAS Number:
28526-44-5
Formula:
C40H56O4
Molwt:
600.87
Pathway:
Proteases/Proteasome|Apoptosis|Angiogenesis|Tyrosine Kinase/Adaptors
SMILES:
C(C(/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/[C@@H]1C(C)(C)C[C@@H](O)C=C1C)\C)\C)/C)/CO)=O)C=2C(C)(C)C[C@H](O)CC2C
Target:
FGFR|Bcl-2 Family|Apoptosis|Caspase

Documents