TargetMol

cMCoFx1

Product Code:
 
TAR-TP2974
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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This product comes from: Austria.
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Further Information

Bioactivity:
cMCoFx1 is an effective and selective FXIIa cyclic peptide inhibitor. It exhibits high binding affinity for FXIIa (KD: 900 pM) and potent inhibitory activity (Ki: 370 pM). cMCoFx1 effectively suppresses the intrinsic coagulation pathway, demonstrates high stability in serum, and shows no cytotoxicity.
CAS Number:
2853605-24-8
Formula:
C146H232N52O44S6
Molwt:
3612.12
Pathway:
Metabolism
SMILES:
O=C1N2[C@@](CCC2)(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]([C@H](CC)C)(C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@]3(CSSC[C@@]4(NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@@]5(CSSC[C@@]1(NC(=O)[C@]([C@H](CC)C)(NC(=O)CNC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC6=CC=C(O)C=C6)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@](CSSC[C@@](C(=O)N7[C@](C(=O)NCC(=O)N[C@@H](C)C(=O)N5)(CCC7)[H])(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC3=O)[H])(NC(=O)[C@H](CC8=CC=CC=C8)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC4=O)[H])[H])[H])[H])[H])[H])[H])[H])[H])[H]
Target:
Factor Xa

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