TargetMol

Peptide P60

Product Code:
 
TAR-TP3042
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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This product comes from: Austria.
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Further Information

Bioactivity:
Peptide P60 acts as a FOXP3 inhibitor. This compound can penetrate cells to hinder FOXP3's nuclear translocation and diminish its ability to suppress transcription factors NF-κB and NFAT. Peptide P60 also suppresses the immunosuppressive activity of regulatory T cells (Treg) derived from mice and humans, while enhancing effector T cell stimulation in vitro. Moreover, Peptide P60 can induce a lymphoproliferative autoimmune syndrome, displaying pathological characteristics similar to those observed in scurfy mice lacking functional Foxp3. Additionally, Peptide P60 has the potential to boost the immunogenicity of cancer and viral vaccines.
CAS Number:
1319725-20-6
Formula:
C95H132N24O20S2
Molwt:
1994.34
Pathway:
NF-κB
SMILES:
C([C@@H](C(=O)N1[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@@H](CCSC)C(O)=O)=O)C)=O)=O)=O)CCC1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC([C@@H](NC([C@H](CC5=CC=CC=C5)NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CC(O)=O)=O)=O)CCC(N)=O)=O)CO)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCSC)=O)C=6C=7C(NC6)=CC=CC7
Target:
NF-κB

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